M1/M2 Polarization

Spatial Proteomics
Patient Stratification
Oncology
Immunology
Overview

Macrophages have diverse roles in the human body to fight against foreign pathogens and maintain homeostasis. The polarization of macrophages into M1 and M2 types has been used in clinical research; specifically, M2 macrophages called TAMs (tumor-associated macrophages) are associated with resistance to immunotherapies and poor prognosis of cancers.

This insight report will determine the spatial localization of M1 and M2 macrophages with respect to the tumor and stromal compartments, which may be used to inform outcomes of immunotherapy.

Key Questions Answered
Where are the TAMs in the tumor microenvironment?
Outputs
  1. Quantification of M1 and M2 macrophage frequencies in the tumor microenvironment
  2. Quantification of cellular and spatial features, including cell type frequency, cell-cell interactions, and cell neighborhoods in the context of M1/M2 macrophages
Deliverables
Insights Report
ECP Visualizer
ECP Explorer
Image(s)
Data Plot(s)
Data Table(s)
CSV File(s)